Shimamura K, Sunano S
Research Institute of Hypertension, Kinki University, Osaka, Japan.
Naunyn Schmiedebergs Arch Pharmacol. 1990 Nov;342(5):554-8. doi: 10.1007/BF00169045.
Effects of Bay K 8644 on the spontaneous electrical and mechanical activities of the rat portal vein were studied. Bay K 8644 enhanced contractions in amplitude and duration. Bay K 8644 prolonged the duration of the spontaneous spike potential bursts and increased the number of spike potentials in a burst. These results indicate that the increase in the amplitude and duration of spontaneous contractions of the rat portal vein induced by Bay K 8644 are mediated mainly by the facilitation of the membrane electrical activity.
研究了Bay K 8644对大鼠门静脉自发电活动和机械活动的影响。Bay K 8644增强了收缩的幅度和持续时间。Bay K 8644延长了自发尖峰电位爆发的持续时间，并增加了一次爆发中尖峰电位的数量。这些结果表明，Bay K 8644诱导的大鼠门静脉自发收缩幅度和持续时间的增加主要是由膜电活动的促进介导的。
