硝普钠、甲氧基维拉帕米（D600）和硝苯地平对大鼠门静脉的某些作用。
Some effects of sodium nitroprusside, methoxyverapamil (D600) and nifedipine on rat portal vein.
作者信息
Jetley M, Weston A H
出版信息
Br J Pharmacol. 1980 Feb;68(2):311-9. doi: 10.1111/j.1476-5381.1980.tb10420.x.
Abstract
1 The effects of methoxyverapamil (D600), nifedipine and sodium nitroprusside on noradrenaline-induced electrical and mechanical activity in rat portal vein have been examined. 2 D600 and nifedipine produced a concentration-dependent reduction in mechanical responses to noradrenaline whilst sodium nitroprusside had no effect. The effects of D600 and nifedipine were reversed by increasing the extracellular calcium concentration. 3 The mechano-inhibitory effects of D600 were accompanied by a marked reduction in electrical activity with some evidence of electromechanical uncoupling. 4 The mechano-inhibitory effects of nifedipine were associated with considerable electromechanical uncoupling. 5 It is concluded that in the concentrations used, D600 acts primarily by inhibiting calcium influx with some effect on electromechanical coupling whilst nifedipine interferes mainly with the coupling process. The inactivity of sodium nitroprusside suggests that the excitation-contraction coupling process in rat portal vein is relatively simple and further studies with this tissue seem indicated.
摘要
- 已研究了甲氧基维拉帕米（D600）、硝苯地平和硝普钠对去甲肾上腺素诱导的大鼠门静脉电活动和机械活动的影响。2. D600和硝苯地平对去甲肾上腺素的机械反应产生浓度依赖性降低，而硝普钠无此作用。增加细胞外钙浓度可逆转D600和硝苯地平的作用。3. D600的机械抑制作用伴随着电活动的显著降低，并伴有一些电机械解偶联的证据。4. 硝苯地平的机械抑制作用与相当程度的电机械解偶联有关。5. 得出结论：在所使用的浓度下，D600主要通过抑制钙内流起作用，对电机械偶联有一定影响，而硝苯地平主要干扰偶联过程。硝普钠无活性表明大鼠门静脉中的兴奋 - 收缩偶联过程相对简单，似乎需要对该组织进行进一步研究。
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