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正常和肿瘤性大肠黏膜中表皮生长因子受体的分子测定

Molecular determination of epidermal growth factor receptor in normal and neoplastic colorectal mucosa.

作者信息

Piazzi G, Paterini P, Ceccarelli C, Pantaleo M A, Biasco G

机构信息

1Centre of Applied Biomedical Research (CRBA), S Orsola-Malpighi Hospital, University of Bologna, Via Massarenti 9, Bologna 40138, Italy.

出版信息

Br J Cancer. 2006 Dec 4;95(11):1525-8. doi: 10.1038/sj.bjc.6603441. Epub 2006 Oct 31.

DOI:10.1038/sj.bjc.6603441
PMID:17088913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2360732/
Abstract

The epidermal growth factor receptor (EGFr) is considered a major target for treatment of colorectal cancer (CRC). We found a mean EGFr content significantly lower but more activated in colonic neoplastic tissue than in paired normal mucosa. Phosphorylated (pY1068) EGFr detection in CRC may be a better tool than EGFr detection to select patients for targeted therapies.

摘要

表皮生长因子受体（EGFr）被认为是治疗结直肠癌（CRC）的主要靶点。我们发现，与配对的正常黏膜相比，结肠肿瘤组织中的EGFr平均含量显著降低，但活性更高。在结直肠癌中检测磷酸化（pY1068）EGFr可能比检测EGFr是选择靶向治疗患者的更好工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0654/2360732/f0f62d6d5aba/95-6603441f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0654/2360732/f0f62d6d5aba/95-6603441f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0654/2360732/f0f62d6d5aba/95-6603441f1.jpg

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活化 EGFR 表达对人结肠癌的预后影响：与 EGFR 状态的比较。
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