McLellan R, Buscema J, Currie J L, Woodruff J D
Division of Gynecologic Oncology, Johns Hopkins Hospital, Baltimore, Maryland.
Am J Clin Pathol. 1991 May;95(5):670-5. doi: 10.1093/ajcp/95.5.670.
Placental site trophoblastic tumor is a rare neoplasm that arises in the trophoblastic tissue of the placental bed. This case report is unusual because of the patient's advanced age at the time of diagnosis and the favorable response of the disease to chemotherapy. Although the clinical course is benign for most patients with placental site trophoblastic tumor, the malignant variant of the disease is characterized by recurrence, relative insensitivity to radiation and chemotherapy, and death. To the authors' knowledge, the 53-year-old woman reported is the oldest patient with histologically confirmed placental site trophoblastic tumor. Initially, surgery, radiation, and multiagent chemotherapy failed to control vaginal and pulmonary metastatic disease. After administration of four treatment cycles of a "second-line" chemotherapeutic regimen consisting of cyclophosphamide and cisplatin, complete clinical and radiologic remission was achieved. The patient's serum level of human chorionic gonadotropin has remained undetectable, and she has been without measurable evidence of disease for 16 months.
胎盘部位滋养细胞肿瘤是一种罕见的肿瘤，起源于胎盘床的滋养细胞组织。该病例报告不同寻常，因为患者诊断时年龄较大，且疾病对化疗反应良好。虽然大多数胎盘部位滋养细胞肿瘤患者的临床病程是良性的，但该疾病的恶性变体具有复发、对放疗和化疗相对不敏感以及死亡的特点。据作者所知，报告的这位53岁女性是组织学确诊的胎盘部位滋养细胞肿瘤患者中年龄最大的。最初，手术、放疗和多药化疗未能控制阴道和肺部转移疾病。在给予由环磷酰胺和顺铂组成的“二线”化疗方案四个治疗周期后，实现了临床和影像学完全缓解。患者的血清人绒毛膜促性腺激素水平一直未检测到，并且16个月来一直没有可测量的疾病证据。
