Airede K I
Department of Paediatrics, Faculty of Medical Sciences, University of Jos, Nigeria.
Ann Trop Paediatr. 1990;10(4):363-8. doi: 10.1080/02724936.1990.11747458.
A case of a premature baby who had the classical problems associated with congenital tuberculosis and presented a difficult diagnostic problem is described. Diagnosis was ultimately confirmed by liver biopsy. Treatment was initially with isoniazid alone, followed 2 weeks later by isoniazid and rifampicin. Isoniazid was replaced by ethambutol when an isoniazid-resistant culture was obtained. The baby responded extremely well to therapy and, at 2-year follow-up, was growing satisfactorily without any sequelae. To my knowledge, this is the first case of congenital tuberculosis with a miliary spread to be seen, treated and followed up in the developing world, where tuberculosis is prevalent.
本文描述了一例早产婴儿，其出现了与先天性结核病相关的典型问题，诊断面临困难。最终通过肝活检确诊。治疗最初仅使用异烟肼，2周后加用利福平。当培养出对异烟肼耐药的菌株时，异烟肼被乙胺丁醇替代。该婴儿对治疗反应极佳，在2年随访时，生长发育良好，无任何后遗症。据我所知，这是在结核病流行的发展中国家首次见到、治疗并随访的先天性粟粒型结核病病例。
