Le Doare Kirsty, Barber Nathaniel, Doerholt Katja, Sharland Mike
Department of Paediatrics, Croydon University Hospital, London, UK.
BMJ Case Rep. 2013 Jan 25;2013:bcr2012008207. doi: 10.1136/bcr-2012-008207.
Little evidence is available on the pharmacokinetics of antituberculous medication in premature infants. We report rifampicin (RMP) pharmacokinetics in an extremely premature, low-birthweight female infant born to a mother with known miliary tuberculosis. Intravenous RMP, isoniazid (INH), ciprofloxacin and amikacin were used, as the enteral route was not possible. Area under the curve calculations revealed low average RMP concentrations at doses of 5-10 mg/kg. We review the literature with regard to the dosing regimen and therapeutic drug levels of RMP and INH in premature infants and discuss issues of management. Evidence from this case suggests 10 mg/kg/day is the minimum dose required.
关于早产儿抗结核药物的药代动力学，目前可用的证据很少。我们报告了一名极低出生体重的早产女婴的利福平（RMP）药代动力学情况，其母亲患有粟粒性肺结核。由于无法采用肠内给药途径，因此使用了静脉注射的RMP、异烟肼（INH）、环丙沙星和阿米卡星。曲线下面积计算显示，在剂量为5-10mg/kg时，RMP的平均浓度较低。我们回顾了有关早产儿RMP和INH给药方案及治疗药物水平的文献，并讨论了管理问题。该病例的证据表明，10mg/kg/天是所需的最小剂量。
