Le V N P, Leterme P, Gayot A, Flament M P
Faculté des Sciences Pharmaceutiques et Biologiques, Laboratoire de Pharmacotechnie Industrielle, rue du Professeur Laguesse, BP 83, 59006 LILLE, France.
PDA J Pharm Sci Technol. 2006 Sep-Oct;60(5):314-22.
The aim of this work is to characterize the aerosols obtained by jet nebulization with cyclodextrin solutions and to study the influence of operating conditions on nebulization efficiency. Two cyclodextrins, an hydroxypropyl cyclodextrin (Kleptose HP) and a polydisperse methyl beta cyclodextrin (Crysmeb), were tested with 14 nebulizers that differ geometrically. We first determined the physicochemical properties of density, viscosity, and surface tension for the cyclodextrin solutions. Nebulization efficiency was evaluated by measuring droplet size, nebulization rate, quantity of solution nebulized, and nebulization time. We studied the influence of the technological parameters of pressure and nebulizer type and the influence of the formulation on performance efficiency. The use of different nebulizers and different pressure conditions results in variable efficiency. Regardless of the type of nebulizer, an increase in pressure decreases droplet size and increases nebulization rate. The influence of the nebulizer design is considerable. The aqueous cyclodextrin solutions studied can generate aerosols in particle size ranges suitable for pulmonary deposition. Large quantities of aerosol can be nebulized in acceptable nebulization times. The cyclodextrin concentration does not modify nebulization efficiency in the range tested.
这项工作的目的是表征用环糊精溶液通过喷射雾化获得的气溶胶，并研究操作条件对雾化效率的影响。测试了两种环糊精，一种羟丙基环糊精（Kleptose HP）和一种多分散甲基β-环糊精（Crysmeb），使用了14种几何形状不同的雾化器。我们首先测定了环糊精溶液的密度、粘度和表面张力等物理化学性质。通过测量液滴大小、雾化速率、雾化的溶液量和雾化时间来评估雾化效率。我们研究了压力和雾化器类型等工艺参数的影响以及配方对性能效率的影响。使用不同的雾化器和不同的压力条件会导致效率变化。无论雾化器类型如何，压力增加都会减小液滴大小并提高雾化速率。雾化器设计的影响相当大。所研究的环糊精水溶液能够产生适合肺部沉积的粒径范围内的气溶胶。在可接受的雾化时间内可以雾化大量气溶胶。在所测试的范围内，环糊精浓度不会改变雾化效率。
