Nasongkla Norased, Bey Erik, Ren Jimin, Ai Hua, Khemtong Chalermchai, Guthi Jagadeesh Setti, Chin Shook-Fong, Sherry A Dean, Boothman David A, Gao Jinming
Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390, USA.
Nano Lett. 2006 Nov;6(11):2427-30. doi: 10.1021/nl061412u.
We describe the development of multifunctional polymeric micelles with cancer-targeting capability via alpha(v)beta(3) integrins, controlled drug delivery, and efficient magnetic resonance imaging (MRI) contrast characteristics. Doxorubicin and a cluster of superparamagnetic iron oxide (SPIO) nanoparticles were loaded successfully inside the micelle core. The presence of cRGD on the micelle surface resulted in the cancer-targeted delivery to alpha(v)beta(3)-expressing tumor cells. In vitro MRI and cytotoxicity studies demonstrated the ultrasensitive MRI imaging and alpha(v)beta(3)-specific cytotoxic response of these multifunctional polymeric micelles.
我们描述了通过α(v)β(3)整合素具有癌症靶向能力、可控药物递送以及高效磁共振成像（MRI）造影特性的多功能聚合物胶束的研发情况。阿霉素和一组超顺磁性氧化铁（SPIO）纳米颗粒成功负载于胶束核心内部。胶束表面存在的cRGD导致其靶向递送至表达α(v)β(3)的肿瘤细胞。体外MRI和细胞毒性研究证明了这些多功能聚合物胶束具有超灵敏的MRI成像和α(v)β(3)特异性细胞毒性反应。
