Brandao Neto J, Vieira J G, Shuhama T, Russo E M, Piesco R V, Curi P R
Endocrine-Metabolic Units, Universidade Estadual Paulista, Botucatu-SP, Brazil.
Biol Trace Elem Res. 1991 Feb;28(2):123-33. doi: 10.1007/BF02863078.
Reports in the literature have shown that acute or chronic zinc administration may cause hyperglycemia, with a fall in serum or insular insulin occurring in experimental animals. On the other hand, under conditions of both acute and chronic hyperglycemia, an increase, a decrease, or a normal level of blood zinc has been observed in studies conducted on humans. Thus, the objective of the investigation described here was to determine the relationship existing among zinc, glucose, and insulin under acute conditions. Thirty-six subjects of both sexes (mean age, 23 yr) were tested at 7:00 A.M. after a 12-h fast. Two antecubital veins of both forearms were punctured and maintained with physiological saline. Three experiments were performed in which zinc was administered orally, and hypertonic glucose and tolbutamid were administered intravenously. Blood samples were then collected over a period ranging from 93 to 240 min after the basal times of -30 and 0 min. Hyperzincemia did not cause changes in plasma glucose or insulin either in the absence of or during perfusion of glucose. Hyperglycemia, hypoglycemia, and hyperinsulinemia did not modify serum zinc levels. These results demonstrate that acute zinc administration did not change carbohydrate metabolism and that sudden variations in glucose and insulin levels did not modify the serum profile of zinc.
文献报道显示，急性或慢性给予锌可能会导致高血糖，实验动物会出现血清胰岛素或胰岛胰岛素水平下降。另一方面，在急性和慢性高血糖情况下，对人类进行的研究观察到血锌水平有升高、降低或正常的情况。因此，本文所述研究的目的是确定急性条件下锌、葡萄糖和胰岛素之间存在的关系。36名男女受试者（平均年龄23岁）在禁食12小时后的上午7点进行测试。穿刺双侧前臂的两条肘前静脉，并用生理盐水维持。进行了三项实验，分别口服锌、静脉注射高渗葡萄糖和甲苯磺丁脲。然后在基础时间-30分钟和0分钟后的93至240分钟内采集血样。在无葡萄糖灌注或葡萄糖灌注期间，高锌血症均未引起血浆葡萄糖或胰岛素的变化。高血糖、低血糖和高胰岛素血症均未改变血清锌水平。这些结果表明，急性给予锌不会改变碳水化合物代谢，葡萄糖和胰岛素水平的突然变化也不会改变锌的血清水平。
