Zhang De-Gang, Zhao Ying, Xia Pei-Jin, Huang Xiao-Qun, Liu Zhi-Min, Zhou Hui
Department of Neurology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China.
Zhong Xi Yi Jie He Xue Bao. 2006 Nov;4(6):601-5. doi: 10.3736/jcim20060612.
To investigate the effects of Tongluo Recipe (TLR), a compound Chinese herbal medicine, on experimental diabetic peripheral neuropathy in rats.
Diabetes was induced by streptozocin in rats. Eight weeks later, the diabetic rats were assigned to 3 groups according to different body weights: untreated group, low-dose TLR-treated group and high-dose TLR-treated group. Eight normal rats were assigned to normal control group. Systemic and sciatic nerve intrinsic antioxidant enzyme activities, lipid peroxide levels, hemorheology and sciatic nerve conduction velocity and ultrastructure changes were evaluated.
Glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were lower, and lipid peroxide levels were higher in plasma and sciatic nerve of the untreated group than those in the normal control group (P<0.05). Blood glucose and viscosity in the untreated group were higher than those in the normal control group. Sciatic nerve showed demyelination changes and decrease of conduction velocity. Vasa nervorum expanded and erythrocyte deposited in the capillary in the untreated group. TLR obviously improved sciatic nerve conduction velocity and ameliorated morphology changes, decreased blood viscosity, improved SOD and GSH-Px activities.
TLR can obviously improve sciatic nerve function and ameliorate morphology changes in rats with diabetic peripheral neuropathy, probably through depleting free radical production, improving endothelial cell function and ameliorating hemorheology changes.
研究复方中药通络方（TLR）对大鼠实验性糖尿病周围神经病变的影响。
用链脲佐菌素诱导大鼠患糖尿病。八周后，根据体重将糖尿病大鼠分为3组：未治疗组、低剂量TLR治疗组和高剂量TLR治疗组。将8只正常大鼠分为正常对照组。评估全身及坐骨神经内抗氧化酶活性、脂质过氧化物水平、血液流变学以及坐骨神经传导速度和超微结构变化。
未治疗组血浆和坐骨神经中谷胱甘肽过氧化物酶（GSH-Px）和超氧化物歧化酶（SOD）活性低于正常对照组，脂质过氧化物水平高于正常对照组（P<0.05）。未治疗组血糖和血液黏度高于正常对照组。坐骨神经出现脱髓鞘改变且传导速度降低。未治疗组神经血管扩张，红细胞沉积于毛细血管中。TLR明显改善了坐骨神经传导速度，减轻了形态学改变，降低了血液黏度，提高了SOD和GSH-Px活性。
TLR可能通过减少自由基生成、改善内皮细胞功能和减轻血液流变学改变，明显改善糖尿病周围神经病变大鼠的坐骨神经功能并减轻形态学改变。
