Li Xiang, Liu Yuan-Fen, Xiang Xiao-Ren, Zhou Yi-Biao, Zhang Zhi-Lei
Department of Medicinal Chemistry, College of Pharmacy, Nanjing University of Traditional Chinese Medicine, Nanjing, Jiangsu Province 210029, China.
Zhong Xi Yi Jie He Xue Bao. 2006 Nov;4(6):624-7. doi: 10.3736/jcim20060617.
To investigate the effects of Gypsum Fibrosum and Gypsum Fibrosum Preparatum in promoting granulation.
The wounds of muscle layer were produced in rats by using surgical operation. Two round wounds, with diameter about 1.5 cm, were cut at the depilatory area of two sides of the back of each rat, with an interval of 2 cm, deep to muscle layer, and the thickness of the knife wound of muscle layer was about 0.15 cm. Forty SD rats with the wounds were randomly divided into 4 groups: untreated group, beifuji-treated group, Gypsum Fibrosum-treated group and Gypsum Fibrosum Preparatum-treated group, with 10 rats in each group. Then the wounds were sprinkled with powders of Gypsum Fibrosum and Gypsum Fibrosum Preparatum, or sprayed with beifuji solution, respectively. The healing state of granulation tissues of the wounds was observed at the eighth and fourteenth day respectively.
The number of fibroblasts, the number of capillary tubes and the area of capillary tubes in granulation tissue of wounds in the Gypsum Fibrosum Preparatum-treated group were significantly higher than those in the untreated group and Gypsum Fibrosum-treated group (P<0.01). There were no statistical differences between the Gypsum Fibrosum Preparatum-treated group and the beifuji-treated group. However, Gypsum Fibrosum-treated group showed no obvious differences compared to the untreated group (P>0.05).
Gypsum Fibrosum Preparatum can accelerate the formation of collagenoblast and micrangium in wounds, and the proliferation of granulation tissues, thus promoting the skin wounds to healing. The effect of Gypsum Fibrosum is changed after being calcined, and Gypsum Fibrosum Preparatum has obvious effect in promoting granulation.
探讨生石膏与煅石膏在促进肉芽生长方面的作用。
采用手术方法在大鼠身上制造肌层伤口。在每只大鼠背部脱毛区两侧各切一个直径约1.5 cm的圆形伤口，间隔2 cm，深至肌层，肌层刀伤口厚度约0.15 cm。将40只造伤的SD大鼠随机分为4组：未处理组、贝复济处理组、生石膏处理组和煅石膏处理组，每组10只。然后分别在伤口上撒生石膏和煅石膏粉末，或喷洒贝复济溶液。分别在第8天和第14天观察伤口肉芽组织的愈合状态。
煅石膏处理组伤口肉芽组织中成纤维细胞数量、毛细血管数量及毛细血管面积均显著高于未处理组和生石膏处理组（P<0.01）。煅石膏处理组与贝复济处理组之间无统计学差异。然而，生石膏处理组与未处理组相比无明显差异（P>0.05）。
煅石膏可加速伤口中成纤维细胞和微血管的形成，促进肉芽组织增生，从而促进皮肤伤口愈合。生石膏煅烧后作用发生改变，煅石膏在促进肉芽生长方面有明显作用。
