Uyemura K, Kitamura K
Department of Physiology, Keio University, School of Medicine, Tokyo, Japan.
Comp Biochem Physiol C Comp Pharmacol Toxicol. 1991;98(1):63-72.
Myelin proteins in mammalian peripheral nerve were studied comparatively. 1. While each content of P1 and P2 in the myelin varied among species, additional content of P1 and P2 are relatively constant. 2. The antigenic determinants of P2 for induction of experimental allergic neuritis were reported. 3. Amino acid sequence analysis of P0 revealed that P0 is conserved across species and belongs to the immunoglobulin superfamily. 4. The characteristic carbohydrate chain of P0 containing sulfate and sialic acid showed a positive reaction to the molecule-related immunity and adhesion. 5. Molecular architecture of the myelin is discussed.
对哺乳动物周围神经中的髓磷脂蛋白进行了比较研究。1. 虽然髓磷脂中P1和P2的各自含量在不同物种间有所差异，但P1和P2的额外含量相对恒定。2. 报道了P2诱导实验性变应性神经炎的抗原决定簇。3. P0的氨基酸序列分析表明，P0在物种间保守，属于免疫球蛋白超家族。4. 含有硫酸酯和唾液酸的P0特征性糖链对分子相关免疫和黏附呈阳性反应。5. 对髓磷脂的分子结构进行了讨论。
