Rojas Antonia M, Gonzalez Pedro A, Antipov Eugene, Klibanov Alexander M
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Biotechnol Lett. 2007 Feb;29(2):227-32. doi: 10.1007/s10529-006-9228-y. Epub 2006 Nov 8.
A complex formation between hemin and a congruous oligonucleotide not only greatly enhances the former's peroxidative activity but also results in a biocatalyst (DNAzyme) with a novel specificity. Herein substrate, regio-, enantiomeric, and diastereomeric selectivities of heme, the DNAzyme, and the enzyme horseradish peroxidase are comparatively examined.
血红素与适配寡核苷酸之间形成的复合物不仅极大地增强了前者的过氧化活性，还产生了一种具有新特异性的生物催化剂（脱氧核酶）。本文对血红素、脱氧核酶和辣根过氧化物酶的底物、区域、对映体和非对映体选择性进行了比较研究。
