Kelleher R S, Hann L E, Edwards J A, Sullivan D A
Department of Ophthalmology, Harvard Medical School, Boston, MA.
J Immunol. 1991 May 15;146(10):3405-12.
Androgens regulate the synthesis and secretion of secretory component (SC), the IgA antibody receptor, by acinar cells from the lacrimal gland. However, this hormone action may be susceptible to significant modification by other agents from the endocrine, nervous, or immune systems. To investigate the nature of this neuroimmunoendocrine interaction, the present study examined the impact of hormones, neurotransmitters, and lymphokines on basal and androgen-induced SC production by lacrimal gland acinar cells in vitro. Our results demonstrated that vasoactive intestinal peptide, the beta-adrenergic agonist, isoproterenol, PGE2, IL-1 alpha, IL-1 beta, and TNF-alpha significantly increased media SC levels in control or androgen-containing cell cultures. In contrast, the cholinergic agonist, carbachol, significantly decreased cellular SC output. These effects may be mediated through the agents' known capacity to alter intracellular cAMP levels. In support of this hypothesis, exposure of acinar cells to stimulators or analogues of cAMP resulted in a significant enhancement of SC production. Thus, these findings indicate that SC output in lacrimal tissue may be modulated by interactions between the endocrine, nervous and immune systems.
雄激素可调节泪腺腺泡细胞合成与分泌分泌成分（SC），即IgA抗体受体。然而，这种激素作用可能会受到来自内分泌、神经或免疫系统的其他因子的显著影响。为了研究这种神经免疫内分泌相互作用的本质，本研究检测了激素、神经递质和淋巴因子对体外培养的泪腺腺泡细胞基础及雄激素诱导的SC产生的影响。我们的结果表明，血管活性肠肽、β-肾上腺素能激动剂异丙肾上腺素、PGE2、IL-1α、IL-1β和TNF-α可显著提高对照或含雄激素细胞培养物中的培养基SC水平。相反，胆碱能激动剂卡巴胆碱可显著降低细胞的SC分泌量。这些作用可能是通过这些因子已知的改变细胞内cAMP水平的能力介导的。为支持这一假说，将腺泡细胞暴露于cAMP刺激剂或类似物可导致SC产生显著增加。因此，这些发现表明，泪腺组织中的SC分泌可能受到内分泌、神经和免疫系统之间相互作用的调节。
