Boucher M, Dubray C, Li J H, Paire M, Duchêne-Marullaz P
INSERM U195, Faculty of Medicine, CHU St-Jacques, Clermont-Ferrand, France.
J Cardiovasc Pharmacol. 1991 Feb;17(2):199-206. doi: 10.1097/00005344-199102000-00004.
The effects of pentobarbital and chloralose on the atrial effective refractory period (AERP), atrial and ventricular rates, and mean blood pressure and also on the effects of quinidine on the same parameters were investigated in dogs with chronic atrioventricular block and implanted atrial pacing electrodes. Pentobarbital (30 mg/kg) increased the AERP by up to 12%, atrial and ventricular rates by 39 and 40%, respectively, and after initial lowering (48%) it increased the mean blood pressure (46%). Chloralose (100 mg/kg) increased the AERP (less than 30 min) by up to 7%, the atrial rate by 49%, the ventricular rate (less than 5 min) by 18%, and the mean blood pressure by 47%. In conscious dogs, quinidine at cumulative doses of 2, 4, and 8 mg/kg, i.e., at plasma levels between 2.7 +/- 0.6 and 6.3 +/- 1.3 micrograms/ml, increased the AERP by up to 21, 28, and 46%, the atrial rate by 49, 65, and 72%, and the ventricular rate (less than or equal to 5 min) by 17, 14, and 14%, and lowered the mean blood pressure by 19, 33, and 43%, respectively. Pentobarbital increased the quinidine-induced lengthening of the AERP by up to 10, 21, and 25 ms, respectively, and reduced the corresponding atrial (38, 53, and 67 beats/min) and ventricular (4, 4, and 5 beats/min) chronotropic effects. In contrast, chloralose reduced the quinidine-induced lengthening of the AERP (5, 12, and 22 ms, respectively), but did not modify the corresponding atrial and ventricular chronotropic effects. Neither pentobarbital nor chloralose altered quinidine plasma levels or the hypotensive effects of this drug.(ABSTRACT TRUNCATED AT 250 WORDS)
在患有慢性房室传导阻滞并植入心房起搏电极的犬中，研究了戊巴比妥和氯醛糖对心房有效不应期（AERP）、心房率和心室率、平均血压的影响，以及奎尼丁对相同参数的影响。戊巴比妥（30mg/kg）使AERP增加高达12%，心房率和心室率分别增加39%和40%，在最初降低（48%）后，平均血压升高（46%）。氯醛糖（100mg/kg）使AERP（小于30分钟）增加高达7%，心房率增加49%，心室率（小于5分钟）增加18%，平均血压增加47%。在清醒犬中，累积剂量为2、4和8mg/kg的奎尼丁，即血浆水平在2.7±0.6至6.3±1.3μg/ml之间时，使AERP增加高达21%、28%和46%，心房率增加49%、65%和72%，心室率（小于或等于5分钟）增加17%、14%和14%，平均血压分别降低19%、33%和43%。戊巴比妥分别使奎尼丁诱导的AERP延长增加高达10、21和25毫秒，并降低相应的心房（38、53和67次/分钟）和心室（4、4和5次/分钟）变时作用。相比之下，氯醛糖减少了奎尼丁诱导的AERP延长（分别为5、12和22毫秒），但未改变相应的心房和心室变时作用。戊巴比妥和氯醛糖均未改变奎尼丁的血浆水平或该药物的降压作用。（摘要截短于250字）
