Chaikomin Reawika, Russo Antonietta, Rayner Christopher K, Feinle-Bisset Christine, O'Donovan Deirdre G, Horowitz Michael, Jones Karen L
Discipline of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace Adelaide, South Australia, Australia.
Br J Nutr. 2006 Nov;96(5):883-7. doi: 10.1017/bjn20061922.
The rate of alcohol absorption is dependent on gastric emptying (GE). As the slowing of GE by fat is dependent on lipolysis, orlistat may increase the rise in blood alcohol when alcohol is consumed with, or after, fat. The aim of the study was to evaluate the effects of orlistat on GE and blood alcohol after an alcohol-containing drink following a fat 'preload', in healthy subjects. Ten healthy males consumed 120 ml cream with or without 120 mg orlistat, 30 min before an alcohol-containing drink labelled with 20 MBq [(99 m)Tc]sulfur colloid on 2 d. GE, plasma alcohol and blood glucose were measured. GE was slightly faster with orlistat (P<0.05) compared with control. Plasma alcohol at 15 min was slightly higher with orlistat (0.034 (SEM 0.006) g/100 ml) v. control (0.029 (SEM 0.005) g/100 ml) (P<0.05), but there was no effect on the area under the curve 0-240 min. The increase in blood glucose was greater with orlistat, for example, at 15 min (1.07 (SEM 0.2) mmol/l) v. control (0.75 (SEM 0.2) mmol/l) (P=0.05). The rise in blood glucose and plasma alcohol were related (for example, at 15 min r 0.49; P=0.03). In conclusion, lipase inhibition accelerates GE of an alcohol-containing drink following a fat 'preload' with a minor increase in the initial rise in plasma alcohol.
酒精吸收速率取决于胃排空（GE）。由于脂肪导致的胃排空减慢取决于脂肪分解，当酒精与脂肪一起食用或在食用脂肪后饮用时，奥利司他可能会使血液酒精含量上升幅度增加。本研究的目的是评估在健康受试者中，脂肪“预负荷”后饮用含酒精饮料时，奥利司他对胃排空和血液酒精含量的影响。10名健康男性在2天内，在饮用标有20MBq [（99m）Tc]硫胶体的含酒精饮料前30分钟，分别食用了含或不含120mg奥利司他的120ml奶油。测量胃排空、血浆酒精含量和血糖。与对照组相比，服用奥利司他时胃排空略快（P<0.05）。服用奥利司他组在15分钟时的血浆酒精含量略高于对照组（0.034（标准误0.006）g/100ml对0.029（标准误0.005）g/100ml）（P<0.05），但对0至240分钟曲线下面积无影响。服用奥利司他时血糖升高幅度更大，例如在15分钟时（1.07（标准误0.2）mmol/l对对照组0.75（标准误0.2）mmol/l）（P=0.05）。血糖升高与血浆酒精含量升高相关（例如，在15分钟时r=0.49；P=0.03）。总之，脂肪酶抑制作用会加速脂肪“预负荷”后含酒精饮料的胃排空，同时使血浆酒精含量的初始上升幅度略有增加。
