Verlinden A, Hesta M, Hermans J M, Janssens G P J
Laboratory of Animal Nutrition, Faculty of Veterinary Medicine, Ghent University, Heidestraat 19, B-9820 Merelbeke, Belgium.
Br J Nutr. 2006 Nov;96(5):936-44. doi: 10.1017/bjn20061912.
Dogs with food allergy are often treated by giving a diet with hydrolysed protein sources. Prebiotics might also be successful in prevention and treatment of allergic disease through their effect on the colonic microflora, analogous to studies on probiotics in allergic children. The present study was set up to investigate the effect of supplementing inulin (IN) to commercial hypoallergenic dog diets on apparent nutrient digestibility, faecal characteristics, haematology and Ig in dogs. Supplementation of 3 % IN did not affect faecal pH, food and water intake and urine production. Compared with the intact protein diet with a limited number of ingredients (L), the diet with a hydrolysed protein source (H) resulted in an increased water intake (P<0.001), which could be due to the osmotic effect of free amino acids. Faeces production was increased by IN due to increased faecal moisture content. Increased faeces production on the H diet was mainly due to a higher DM excretion. Subsequently, the apparent digestibility coefficient (ADC) of DM was lower in the H diet group. A similar result was noted for ADC of diethyl ether extract and crude ash. The ADC of crude protein was higher in the H diet group, whereas IN decreased the ADC of crude protein. Differences in the ADC of crude protein among the different diets disappeared after correction for a higher faecal biomass, except for the dogs fed the L+IN diet. Total faecal IgA concentrations were lower in the H group (P<0.05) because of lower antigenic stimulation of hydrolysed protein, which implies that hydrolysed protein is really hypoallergenic. The present study indicates that the use of hydrolysed protein diets for canine food allergy treatment can affect digestibility and that combination with IN affected apparent protein digestibility but not IgA response.
患有食物过敏的犬类通常通过给予含有水解蛋白来源的饮食来进行治疗。益生元也可能通过其对结肠微生物群的作用成功预防和治疗过敏性疾病，这类似于对过敏性儿童进行的益生菌研究。本研究旨在调查在商业低敏犬粮中添加菊粉（IN）对犬类表观养分消化率、粪便特征、血液学和免疫球蛋白的影响。添加3%的IN对粪便pH值、食物和水摄入量以及尿量没有影响。与成分有限的完整蛋白饮食（L）相比，含有水解蛋白来源的饮食（H）导致水摄入量增加（P<0.001），这可能是由于游离氨基酸的渗透作用。由于粪便水分含量增加，IN导致粪便产量增加。H饮食组粪便产量增加主要是由于干物质排泄量较高。随后，H饮食组干物质的表观消化率系数（ADC）较低。二乙醚提取物和粗灰分的ADC也有类似结果。H饮食组粗蛋白的ADC较高，而IN降低了粗蛋白的ADC。除了喂食L+IN饮食的犬只外，不同饮食之间粗蛋白ADC的差异在校正较高的粪便生物量后消失。H组粪便总IgA浓度较低（P<0.05），因为水解蛋白的抗原刺激较低，这意味着水解蛋白确实是低敏的。本研究表明，使用水解蛋白饮食治疗犬类食物过敏会影响消化率，并且与IN联合使用会影响表观蛋白消化率，但不会影响IgA反应。
