Billard C, Autret A, Lucas B, Degiovanni E, Gillet P, Santini J J, de Toffol B
Centre Hospitalier Universitaire, France.
Neurophysiol Clin. 1990 Dec;20(6):439-53. doi: 10.1016/s0987-7053(05)80101-7.
In a population of 11 children with frequent spike waves during non REM sleep who had no neurological symptoms between birth and their first symptom, 3 groups were compared according to their neuropsychological performances. In the first group, the children had no intellectual deficit, in the second group, they had an acquired aphasia as in the Landau-Kleffner syndrome and in the third they had severe behavioural disorder and mental deterioration. The non REM sleep paroxysmic activity density tended to be highest in the third group, variable in the second group and moderate in the first group, and their topography was always generalized in the acute phase in groups II and III but asymmetrical in group I. The EEG anomalies disappeared during adolescence but in group II and III children a moderate to severe delay in school work persisted.
在一群11名非快速眼动睡眠期间频繁出现棘波且出生至首次出现症状期间无神经症状的儿童中，根据他们的神经心理表现比较了3组。第一组儿童无智力缺陷，第二组儿童出现了如Landau-Kleffner综合征那样的获得性失语症，第三组儿童有严重行为障碍和智力衰退。非快速眼动睡眠阵发性活动密度在第三组往往最高，在第二组变化不定，在第一组中等，其地形图在急性期在第二组和第三组总是广泛性的，但在第一组是不对称的。脑电图异常在青春期消失，但在第二组和第三组儿童中，学业中度至重度延迟仍然存在。
