Gottlieb Alice B, Mease Philip J, Mark Jackson J, Eisen Drore, Amy Xia H, Asare Charles, Stevens Seth R
Department of Dermatology, Tufts-New England Medical Center, Boston, MA 02111, USA.
J Dermatolog Treat. 2006;17(5):279-87. doi: 10.1080/09546630600823369.
To describe the skin and joint disease of patients with psoriatic arthritis being treated in dermatology clinics.
A total of 1122 patients who had active psoriatic arthritis were enrolled in a Phase 4, non-randomized, open-label, single-arm, 24-week study. They were treated at 108 community and 17 academic dermatology centers. These patients experienced clinically stable, plaque psoriasis involving > or =10% body surface area and joint disease (either > or = two swollen and > or = two tender/painful joints for > or =3 months, or > or = one joint with sacroiliitis or spondylitis).
In general, patient demographics and disease characteristics did not appear to differ between academic and community dermatology sites. Based on patient-reported assessments, patients rated the severity of their baseline joint symptoms lower than the severity of their skin disease. Baseline skin and joint disease measures were not correlated. Psoriatic arthritis was newly diagnosed in 23% of the patients. Most had received prior therapy for psoriasis, but only half had received systemic therapy for psoriatic arthritis.
Assessment for joint disease in psoriasis patients being treated at dermatology clinics may facilitate earlier psoriatic arthritis diagnosis and treatment initiation, which may prevent disability and other negative impacts.
描述在皮肤科诊所接受治疗的银屑病关节炎患者的皮肤和关节疾病情况。
共有1122例活动性银屑病关节炎患者参加了一项4期、非随机、开放标签、单臂、为期24周的研究。他们在108个社区和17个学术皮肤科中心接受治疗。这些患者患有临床稳定的斑块状银屑病，累及体表面积≥10%，并伴有关节疾病（要么≥两个关节肿胀且≥两个关节压痛/疼痛持续≥3个月，要么≥一个关节患有骶髂关节炎或脊柱炎）。
总体而言，学术性和社区性皮肤科机构的患者人口统计学和疾病特征似乎没有差异。根据患者报告的评估，患者对其基线关节症状严重程度的评分低于皮肤病严重程度。基线皮肤和关节疾病指标不相关。23%的患者新诊断出银屑病关节炎。大多数患者曾接受过银屑病的治疗，但只有一半患者接受过银屑病关节炎的全身治疗。
对在皮肤科诊所接受治疗的银屑病患者的关节疾病进行评估，可能有助于更早地诊断和开始治疗银屑病关节炎，从而预防残疾和其他负面影响。
