Toret Christopher P, Drubin David G
Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720-3202, USA.
J Cell Sci. 2006 Nov 15;119(Pt 22):4585-7. doi: 10.1242/jcs.03251.
Recent live-cell imaging studies, coupled with powerful genetic, biochemical and pharmacological tests of function, have expanded our understanding of the molecular events that underlie clathrin/actin mediated-endocytosis in budding yeast. Many features of this pathway are evolutionarily conserved (Engqvist-Goldstein and Drubin, 2003; Kaksonen et al, 2006). Therefore, insights into the intricate molecular choreography of endocytic events in budding yeast will provide a basis for elucidating such mechanisms in more complex organisms. This poster depicts our current understanding of the dynamics of endocytosis in budding yeast.
最近的活细胞成像研究,结合强大的遗传学、生物化学和功能药理学测试,扩展了我们对出芽酵母中网格蛋白/肌动蛋白介导的内吞作用所涉及分子事件的理解。该途径的许多特征在进化上是保守的(恩qvist - 戈尔茨坦和德鲁宾,2003年;卡克松宁等人,2006年)。因此,深入了解出芽酵母内吞事件复杂的分子编排将为阐明更复杂生物体中的此类机制提供基础。本海报展示了我们目前对出芽酵母内吞作用动力学的理解。