Tazulakhova E B, Mezentseva M V, Ershov F I
Antibiot Khimioter. 1990 Nov;35(11):40-4.
The role of macrophages in production of interferons (IF) is manysided. They are able to synthesize IFs after any induction. However, the function of macrophages as producers of IFs is not, probably, basic. The levels of IFs produced by them are mainly low. When they are stimulated by inducers of "early" IF the synthesis is performed by intact macrophages whereas with the use of inducers of "late" IF there is always observed joint activity of macrophages and other immunocompetent cells. The main role of macrophages in production of IFs is in regulation of synthesis of these proteins in the host. In addition, they are able to serve as stimulating cells in inducing IF production by the majority of drugs by transmitting information on IF synthesis to lymphocytes. This function of macrophages is not species-specific.
巨噬细胞在干扰素（IF）产生过程中的作用是多方面的。在任何诱导之后，它们都能够合成干扰素。然而，巨噬细胞作为干扰素产生者的功能可能并非其主要功能。它们产生的干扰素水平主要较低。当它们受到“早期”干扰素诱导剂刺激时，完整的巨噬细胞就能进行合成，而在使用“晚期”干扰素诱导剂时，总是会观察到巨噬细胞与其他免疫活性细胞的联合活动。巨噬细胞在干扰素产生过程中的主要作用在于调节宿主体内这些蛋白质的合成。此外，它们能够通过将干扰素合成的信息传递给淋巴细胞，充当大多数药物诱导干扰素产生的刺激细胞。巨噬细胞的这一功能并非物种特异性的。
