Filaretova L P, Podvigina T T, Bobryshev P Yu, Bagaeva T R, Tanaka A, Takeuchi K
Laboratory of Experimental Endocrinology, Pavlov Institute of Physiology, nab. Makarova 6, St. Petersburg, 199034, Russia.
Inflammopharmacology. 2006 Dec;14(5-6):207-13. doi: 10.1007/s10787-006-1544-2.
The results overviewed in the present article suggest that glucocorticoids released during acute activation of hypothalamic-pituitary-adrenocortical (HPA) axis are important gastroprotective factors, allowing us to re-evaluate the traditional point of view about their ulcerogenic role. It has been shown that various ulcerogenic stimuli induce an increase in glucocorticoid production that in turn helps the gastric mucosa to resist against a harmful action of ulcerogenic stimuli. Glucocorticoids released in response to mild stress contribute to adaptive gastric cytoprotection. The gastroprotective action of glucocorticoids is accounted for by maintaining the local defensive factors and inhibiting the pathogenic elements. Maintenance of glucose and temperature homeostasis as well as systemic blood pressure by glucocorticoid hormones could be a fundamental of their beneficial action on various gastric targets. Thus, glucocorticoids released during activation of HPA axis may contribute to the gastric mucosal homeostasis through their contribution to general body homeostasis.
本文综述的结果表明，下丘脑 - 垂体 - 肾上腺皮质（HPA）轴急性激活期间释放的糖皮质激素是重要的胃保护因子，这使我们能够重新评估关于其致溃疡作用的传统观点。研究表明，各种致溃疡刺激会导致糖皮质激素产生增加，进而帮助胃黏膜抵抗致溃疡刺激的有害作用。对轻度应激作出反应而释放的糖皮质激素有助于适应性胃细胞保护。糖皮质激素的胃保护作用是通过维持局部防御因子和抑制致病因素来实现的。糖皮质激素维持葡萄糖、温度稳态以及全身血压可能是其对各种胃靶点产生有益作用的基础。因此，HPA轴激活期间释放的糖皮质激素可能通过促进全身稳态来维持胃黏膜稳态。
