Filaretova L P
Usp Fiziol Nauk. 2014 Jan-Mar;45(1):44-56.
The fact that the disturbance of the normal stress reaction by the elimination of the hypothalamic-pituitary-adrenocortical (HPA) axis's functioning leads to negative effects on the body such as the development and aggravation of diseases proves that stress plays a leading role in maintaining the physical health of the body. Here we demonstrate this on the base of the results of our experimental studies related with gastric ulceration. The results show that the reduction in the stress-induced corticosterone release, or its actions, aggravates stress-caused gastric erosion. The data do not support the traditional paradigm about ulcerogenic role of glucocorticoids in stress and suggest that glucocorticoids released during acute activation of the HPA axis are naturally occurring gastroprotective factors.
通过消除下丘脑 - 垂体 - 肾上腺皮质（HPA）轴功能来干扰正常应激反应，会对身体产生负面影响，如导致疾病的发生和加重，这一事实证明应激在维持身体的身体健康方面起着主导作用。在此，我们基于与胃溃疡相关的实验研究结果来证明这一点。结果表明，应激诱导的皮质酮释放减少或其作用减弱，会加重应激引起的胃糜烂。这些数据不支持关于糖皮质激素在应激中致溃疡作用的传统范式，并表明HPA轴急性激活期间释放的糖皮质激素是天然存在的胃保护因子。
