Gonzalez-Pina Rigoberto, Bueno-Nava Antonio, Montes Sergio, Alfaro-Rodriguez Alfonso, Gonzalez-Maciel Angelica, Reynoso-Robles Rafael, Ayala-Guerrero Fructuoso
Laboratorio de Neuroplasticidad, Torre de Investigación, Instituto Nacional de Rehabilitacion, Mexico City, Mexico.
Neurochem Res. 2006 Dec;31(12):1443-9. doi: 10.1007/s11064-006-9196-6. Epub 2006 Nov 9.
Norepinephrine (NE) plays an important role in motor recovery after brain damage. Most studies concerning NE activity have been performed in the cerebellum, while the role of the pons, the site where the norepinephrinergic locus coeruleus is located, has not yet been elucidated. For this work, we studied the changes in cerebellar and pontine NE content in sham-operated (n = 17), motor cortex injured (n = 6) and recovered rats (n = 12). Motor effects were assessed by means of footprint analysis and sensorimotor evaluation. It was found that after cortical brain damage, the stride length decreases while the stride angle increases after 6 h post-surgery, while the sensorimotor evaluation showed an increase in the motor deficit. Recovery was observed after 24 h. NE content increased in the pons after 6 h and returned to normal levels in recovered rats, with no significant changes observed in the cerebellum. Based on the functional remote inhibition, it is possible that NE exerts an autoinhibitory effect in the pons after motor cortical ablation. On the other hand, the absence of an effect in the cerebellum suggests that cerebellar NE activity related to damage and/or recovery is limited to discrete areas of the structure.
去甲肾上腺素（NE）在脑损伤后的运动恢复中起着重要作用。大多数关于NE活性的研究是在小脑中进行的，而蓝斑去甲肾上腺素能神经元所在的脑桥的作用尚未阐明。在本研究中，我们研究了假手术组（n = 17）、运动皮层损伤组（n = 6）和恢复组大鼠（n = 12）小脑和脑桥中NE含量的变化。通过足迹分析和感觉运动评估来评估运动效果。结果发现，皮质脑损伤后，术后6小时步幅长度缩短而步幅角度增加，同时感觉运动评估显示运动功能缺损增加。24小时后观察到恢复。脑桥中NE含量在6小时后增加，并在恢复组大鼠中恢复到正常水平，小脑中未观察到显著变化。基于功能性远程抑制，运动皮层切除术后NE可能在脑桥中发挥自抑制作用。另一方面，小脑中没有效应表明与损伤和/或恢复相关的小脑NE活性仅限于该结构的离散区域。
