Boulet Sheree L, Correa-Villaseñor Adolfo, Hsia Jason, Atrash Hani
National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA.
Birth Defects Res A Clin Mol Teratol. 2006 Nov;76(11):757-61. doi: 10.1002/bdra.20291.
Nationally representative data on the prevalence of certain birth defects are largely unavailable. We evaluated the feasibility of using data from the National Hospital Discharge Survey (NHDS) to describe the prevalence of selected birth defects.
All live births recorded in the NHDS during 1999-2001 were included. The prevalence for selected birth defects was calculated using weighted ratio estimators. Prevalence ratios comparing the NHDS estimates to published national estimates from the National Birth Defects Prevention Network (NBDPN) were calculated.
With the exception of common truncus, the NHDS prevalence for the selected defects was consistently lower than the NBDPN estimates. The prevalence ratios ranged from 0.38 for trisomy 18 and anopthalmia/micropthalmia to 1.16 for common truncus. The NHDS prevalence estimates for spina bifida without anencephaly (PR 0.89, 95% CI: 0.57-1.22) and gastroschisis/omphalocele (PR 0.94, 95% CF: 0.48-1.40) most closely approximated the NBDPN estimates.
NHDS data underestimate the prevalence of most birth defects. Additional research is needed to determine whether NHDS estimates may be useful for evaluating trends in certain conditions. Surveillance systems employing active case-finding continue to provide more accurate estimates of birth defects prevalence.
关于某些出生缺陷患病率的全国代表性数据基本无法获取。我们评估了使用国家医院出院调查（NHDS）数据来描述特定出生缺陷患病率的可行性。
纳入1999 - 2001年NHDS记录的所有活产儿。使用加权比率估计器计算特定出生缺陷的患病率。计算将NHDS估计值与国家出生缺陷预防网络（NBDPN）公布的全国估计值进行比较的患病率比。
除共同动脉干外，所选缺陷的NHDS患病率始终低于NBDPN的估计值。患病率比范围从18三体综合征和无眼/小眼畸形的0.38到共同动脉干的1.16。无脑儿的脊柱裂（PR 0.89，95% CI：0.57 - 1.22）和腹裂/脐膨出（PR 0.94，95% CF：0.48 - 1.40）的NHDS患病率估计值最接近NBDPN的估计值。
NHDS数据低估了大多数出生缺陷的患病率。需要进一步研究以确定NHDS估计值是否可用于评估某些疾病的趋势。采用主动病例发现的监测系统继续能提供更准确的出生缺陷患病率估计值。
