Fakeye T O, Adegoke A O, Omoyeni O C, Famakinde A A
Department of Clinical Pharmacy and Pharmacy Administration, Faculty of Pharmacy, University of Ibadan, Nigeria.
Phytother Res. 2007 Jan;21(1):96-8. doi: 10.1002/ptr.2019.
The effect of beverages prepared from the dried calyx of the flowers of Hibiscus sabdariffa on the excretion of diclofenac was investigated using a controlled study in healthy human volunteers. A high pressure liquid chromatographic method was used to analyse the 8 h urine samples collected after the administration of diclofenac with 300 mL (equivalent to 8.18 mg anthocyanins) of the beverage administered daily for 3 days. An unpaired two-tailed t-test was used to analyse for significant difference observed in the amount of diclofenac excreted before and after administration of the beverage. There was a reduction in the amount of diclofenac excreted and the wide variability observed in the control with the water beverage of Hibiscus sabdariffa (p < 0.05). There is an increasing need to counsel patients against the use of plant beverages with drugs.
在健康人类志愿者中进行了一项对照研究，以调查用玫瑰茄花干燥花萼制备的饮料对双氯芬酸排泄的影响。采用高压液相色谱法分析在服用双氯芬酸后收集的8小时尿液样本，每天服用300毫升（相当于8.18毫克花青素）该饮料，持续3天。使用不成对双尾t检验分析服用饮料前后双氯芬酸排泄量的显著差异。服用玫瑰茄水饮料后，双氯芬酸的排泄量减少，且在对照组中观察到的广泛变异性降低（p<0.05）。越来越需要告诫患者不要将植物饮料与药物一起使用。
