Bandyopadhyay Sourav, Kelley Ryan, Ideker Trey
Program in Bioinformatics, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA.
Pac Symp Biocomput. 2006:354-66.
Human immunodeficiency virus (HIV) affects millions of people across the globe. Despite the introduction of powerful anti-viral therapies, one factor confounding viral elimination is the ability of HIV to remain latent within the host genome. Here, we perform a network analysis of the viral reactivation process using human gene expression profiles and curated databases of both human-human and human-HIV protein interactions. Based on this analysis, we report the identification of active pathways in both the latent and early phases of reactivation. These active pathways suggest host functions that are altered and important for HIV pathogenesis.
人类免疫缺陷病毒（HIV）影响着全球数百万人。尽管引入了强大的抗病毒疗法，但阻碍病毒清除的一个因素是HIV能够潜伏在宿主基因组中。在此，我们利用人类基因表达谱以及精心整理的人类-人类和人类-HIV蛋白质相互作用数据库，对病毒重新激活过程进行了网络分析。基于这一分析，我们报告了在重新激活的潜伏阶段和早期阶段中活跃途径的识别情况。这些活跃途径表明了宿主功能发生了改变，且对HIV发病机制具有重要意义。
