Castañeda Sanz S, Bruges-Armas J, Herrero-Beaumont G
Hospital de la Princesa, Madrid.
Acta Reumatol Port. 2006 Jul-Sep;31(3):205-13.
Osteoarthritis (OA) is one of the most prevalent diseases of the musculoskeletal system, and it is caused by an unbalance in chondrocyte homeostasis. Although the chondrocyte is considered the key element in the maintenance of cartilage homeostasis, other structures like subchondral bone and synovial membrane are also involved in the development and progression of OA. In fact, OA is considered an example of a global failure of joint structures. In this paper, we will review the role of subchondral bone and synovium in the pathogenesis of OA, as well as their possible therapeutic implications.
骨关节炎（OA）是肌肉骨骼系统最常见的疾病之一，它由软骨细胞内环境稳态失衡引起。尽管软骨细胞被认为是维持软骨内环境稳态的关键因素，但诸如软骨下骨和滑膜等其他结构也参与了骨关节炎的发生和发展。事实上，骨关节炎被认为是关节结构整体功能失效的一个例子。在本文中，我们将综述软骨下骨和滑膜在骨关节炎发病机制中的作用，以及它们可能的治疗意义。
