Herman J H, Appel A M
J Rheumatol. 1987 May;14 Spec No:83-5.
Preservation of the structural integrity of cartilage requires that metabolic homeostasis be maintained between chondrocyte anabolic and catabolic functions. This critical balance is perturbed in osteoarthritis (OA) in which synovial tissue and subchondral intratrabecular marrow often contain a focal and at times more diffuse mononuclear cell infiltration. Cytokines derived from T lymphocytes and monocytes have a capacity to: a) cause qualitative changes in and reversibly suppress chondrocyte proteoglycan, collagen, and non-collagen protein synthesis, and b) induce the synthesis and release of chondrocyte proteinases. Factors having comparable metabolic regulatory activity are produced by synovial tissue derived from idiopathic and secondary forms of OA.
软骨结构完整性的维持需要在软骨细胞合成代谢和分解代谢功能之间保持代谢稳态。骨关节炎（OA）会扰乱这种关键平衡，在OA中，滑膜组织和软骨下小梁内骨髓通常存在局灶性且有时更弥漫性的单核细胞浸润。源自T淋巴细胞和单核细胞的细胞因子能够：a）引起软骨细胞蛋白聚糖、胶原蛋白和非胶原蛋白合成的质的变化并可逆地抑制其合成，以及b）诱导软骨细胞蛋白酶的合成和释放。特发性和继发性OA滑膜组织产生具有类似代谢调节活性的因子。
