Kakimoto Naoya, Inoue Takehiro, Inoue Toshihiko, Murakami Shumei, Furukawa Souhei, Yoshida Ken, Yoshioka Yasuo, Yamazaki Hideya, Tanaka Eiichi, Shimizutani Kimishige
Department of Oral and Maxillofacial Radiology, Osaka University Graduate School of Dentistry, 1-8 Yamadaoka, Osaka 565-0871, Japan.
Anticancer Res. 2006 Sep-Oct;26(5B):3933-7.
It has been demonstrated that the outcome of primary radiotherapy in squamous cell carcinomas of the head and neck is strongly influenced by overall treatment time. The purpose of this study was to evaluate the results of high-dose-rate (HDR) interstitial brachytherapy (ISBT) for early mobile tongue cancer and to examine whether the non-irradiated period affected treatment results.
Seventy-one patients with early mobile tongue cancer (T1-T2N0M0) were treated with HDR ISBT alone. The total dose was 54-60 Gy/9-10 fractions/5-9 days. All patients were classified into 4 groups: R0, maximum non-irradiated period (NIP) was less than 24 h (n=16); R1, maximum NIP was from 24 to 48 h (n=24); R2, maximum NIP was from 48 to 72 h (n=26); R3, maximum NIP was from 72 to 96 h (n=5).
The 3-year local control rate was 94% in R0, 83% in R1, 85% in R2 and 100% in R3. The 3-year overall survival rate was 84% in R0, 92% in R1, 71% in R2 and 80% in R3. There was no significant difference in the local control rate, overall survival rate, or complications among the 4 groups.
In HDR ISBT for early mobile tongue cancer, the non-irradiated period did not affect the treatment results or complications.
已证明头颈部鳞状细胞癌的初次放疗结果受总治疗时间的强烈影响。本研究的目的是评估高剂量率（HDR）组织间近距离放疗（ISBT）治疗早期可活动舌癌的结果，并检查未放疗期是否影响治疗结果。
71例早期可活动舌癌（T1-T2N0M0）患者仅接受了HDR ISBT治疗。总剂量为54-60 Gy/9-10次分割/5-9天。所有患者分为4组：R0组，最大未放疗期（NIP）小于24小时（n=16）；R1组，最大NIP为24至48小时（n=24）；R2组，最大NIP为48至72小时（n=26）；R3组，最大NIP为72至96小时（n=5）。
R0组3年局部控制率为94%，R1组为83%，R2组为85%，R3组为100%。R0组3年总生存率为84%，R1组为92%，R2组为71%，R3组为80%。4组之间的局部控制率、总生存率或并发症无显著差异。
在HDR ISBT治疗早期可活动舌癌时，未放疗期不影响治疗结果或并发症。
