CD2启动子调控的核磷蛋白-间变性淋巴瘤激酶在转基因小鼠中引发B淋巴细胞恶性肿瘤。
CD2 promoter regulated nucleophosmin-anaplastic lymphoma kinase in transgenic mice causes B lymphoid malignancy.
作者信息
Turner Suzanne D, Merz Hartmut, Yeung Debra, Alexander Denis R
机构信息
Laboratory of Lymphocyte Signalling and Development, The Babraham Institute, Babraham Research Campus, Babraham, Cambridge CB2 4AT, UK.
出版信息
Anticancer Res. 2006 Sep-Oct;26(5A):3275-9.
BACKGROUND
Nucleophosmin-anaplastic lymphoma kinase expression is associated with a lymphoid malignancy, anaplastic large cell lymphoma, and is characterized by a t(2;5) chromosomal translocation.
MATERIALS AND METHODS
We describe a novel transgenic mouse line in which NPM-ALK expression is targeted to the T-cell lineage using the CD2 promoter.
RESULTS
Surprisingly, the mice develop B cell lymphomas in the majority of cases.
CONCLUSION
These data stress the importance of choice of promoter to drive transgene expression in obtaining the desired phenotype.
背景
核磷蛋白-间变性淋巴瘤激酶表达与一种淋巴恶性肿瘤——间变性大细胞淋巴瘤相关，其特征为t(2;5)染色体易位。
材料与方法
我们描述了一种新型转基因小鼠品系，其中使用CD2启动子将NPM-ALK表达靶向T细胞谱系。
结果
令人惊讶的是，在大多数情况下，这些小鼠会发生B细胞淋巴瘤。
结论
这些数据强调了在获得所需表型时选择启动子来驱动转基因表达的重要性。
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