Antal István
Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest.
Acta Pharm Hung. 2006;76(3):149-54.
The role of particle size reduction and particle engineering is growing considering the design and manufacturing of drug carrier systems. The objective of the review is to summarize and compare the micronization methods based on particle size reduction and which are applied to improve drug dissolution and bioavailability. These methods are effective especially when suitable pharmaceutical excipients are used by cogrinding. Beside formation of engineered particles, milling remains important to design particles with the desired size, shape and surface characteristics.
考虑到药物载体系统的设计和制造，减小粒径和进行颗粒工程的作用日益凸显。本综述的目的是总结和比较基于粒径减小的微粉化方法，这些方法用于改善药物溶解和生物利用度。当通过共研磨使用合适的药用辅料时，这些方法尤其有效。除了形成工程化颗粒外，研磨对于设计具有所需尺寸、形状和表面特性的颗粒仍然很重要。
