Antal István
Semmelweis Egyetem Gyógyszerészeti Intézet, Budapest.
Acta Pharm Hung. 2006;76(2):95-103.
The role of micronization is growing considering the optimization of the physicochemical characteristics of drug, dissolution enhancement and ensuring appropiate bioavailability. The importance of micronization can be understood on the basis of Noyes-Whitney equation, where the particle characteristics influence the active surface contacting with the dissolution medium, theoretically the solubility, and the boundary layer around the particle under certain hidrodynamic conditions. To adjudge the possibilities and limits of micronization concerning the dosage form design and preparations based on innovative pharmaceutical technology, it is necessary to take the detailed theoretical, physiological and biopharmaceutical aspects into consideration.
考虑到药物理化特性的优化、溶出度的提高以及确保适当的生物利用度，微粉化的作用日益凸显。微粉化的重要性可以基于诺伊斯-惠特尼方程来理解，在该方程中，颗粒特性会影响与溶出介质接触的活性表面，理论上还会影响溶解度以及在特定流体动力学条件下颗粒周围的边界层。为了评判微粉化在基于创新制药技术的剂型设计和制剂方面的可能性和局限性，有必要考虑详细的理论、生理学和生物药剂学方面的因素。
