Bae Jeehyeon, Shin Seung Joo, Cha Sun Hee, Choi Dong Hee, Lee Suman, Kim Nam Keun
Institute for Clinical Research, Bundang CHA General Hospital, College of Medicine, Seongnam, South Korea.
Fertil Steril. 2007 Feb;87(2):351-5. doi: 10.1016/j.fertnstert.2006.06.027. Epub 2006 Nov 13.
To assess prevalent 5,10-methylenetetrahydrofolate reductase (MTHFR) polymorphisms in spontaneously aborted embryos.
A retrospectively analyzed, prospectively obtained database.
Bundang CHA General Hospital and Kangnam CHA Hospital.
PATIENT(S): Ninety-four spontaneously aborted embryos at <20 weeks of gestational age.
INTERVENTION(S): None.
Genotype frequency of MTHFR C677T and A1298C polymorphisms in spontaneously aborted embryos.
RESULT(S): The aborted embryos exhibited both a significantly high frequency of the MTHFR 677CC genotype and a low frequency of the MTHFR 677CT genotype, compared to both the child and the adult control groups, respectively, whereas no significant change in the fetal MTHFR A1298C genotype frequency was observed. The combinative genotype of MTHFR 677CC/1298AC from the abortus had a high prevalence compared to the child controls. Further, the chromosomal integrity of the abortus did not affect the frequency of the MTHFR 677CC and 1298AC genotypes.
Spontaneously aborted embryos have a unique distribution of MTHFR C677T and A1289C polymorphisms, regardless of their chromosomal integrity.
评估自然流产胚胎中5,10-亚甲基四氢叶酸还原酶（MTHFR）基因多态性的流行情况。
一项回顾性分析的前瞻性获取数据库。
盆唐CHA综合医院和江南CHA医院。
94例孕龄小于20周的自然流产胚胎。
无。
自然流产胚胎中MTHFR C677T和A1298C基因多态性的基因型频率。
与儿童和成人对照组相比，流产胚胎中MTHFR 677CC基因型频率显著较高，而MTHFR 677CT基因型频率较低，而胎儿MTHFR A1298C基因型频率未观察到显著变化。与儿童对照组相比，流产胚胎中MTHFR 677CC/1298AC的联合基因型患病率较高。此外，流产胚胎的染色体完整性不影响MTHFR 677CC和1298AC基因型的频率。
自然流产胚胎具有独特的MTHFR C677T和A1289C基因多态性分布，与染色体完整性无关。
