在体外受精周期中，卵泡液中高浓度的乳铁蛋白与胚胎质量相关。
High concentrations of lactoferrin in the follicular fluid correlate with embryo quality during in vitro fertilization cycles.
作者信息
Yanaihara Atsushi, Mitsukawa Kaori, Iwasaki Shinji, Otsuki Katsufumi, Kawamura Toshihiro, Okai Takashi
机构信息
Department of Obstetrics and Gynecology, Showa University School of Medicine, Shinagawa-ku, Tokyo, Japan.
出版信息
Fertil Steril. 2007 Feb;87(2):279-82. doi: 10.1016/j.fertnstert.2006.06.025. Epub 2006 Nov 7.
OBJECTIVE
To investigate the level of lactoferrin (LF) in follicular fluid (FF), as well as the correlation between the LF concentration of FF, fertilization rate, and embryo quality.
DESIGN
Retrospective study.
SETTING
In vitro fertilization program at the Showa University School of Medicine, Tokyo, Japan.
PATIENT(S): Follicular fluid was obtained from 35 IVF patients, aged 25-34 years.
INTERVENTION(S): In total, 70 FF and serum samples were collected at the time of oocyte harvesting (44 of the oocytes were fertilized, and 26 were not). The LF concentration in FF was assayed via ELISA.
RESULT(S): The mean LF concentration in FF of the fertilized group (500.2 +/- 35.5 ng/mL) was significantly higher than that in the unfertilized group (379.7 +/- 45.1 ng/mL). A positive correlation between follicular size and LF concentration was not found (r = 0.214). However, a high LF concentration in FF was indicative of good embryo quality.
CONCLUSION(S): High LF concentrations in FF correlate with both a high fertilization rate and good embryo quality.
目的
研究卵泡液（FF）中乳铁蛋白（LF）的水平，以及FF中LF浓度、受精率和胚胎质量之间的相关性。
设计
回顾性研究。
地点
日本东京昭和大学医学院体外受精项目。
患者
从35名年龄在25至34岁的体外受精患者中获取卵泡液。
干预措施
在取卵时共收集了70份FF和血清样本（其中44个卵母细胞受精，26个未受精）。通过酶联免疫吸附测定法检测FF中的LF浓度。
结果
受精组FF中的平均LF浓度（500.2±35.5 ng/mL）显著高于未受精组（379.7±45.1 ng/mL）。未发现卵泡大小与LF浓度之间存在正相关（r = 0.214）。然而，FF中LF浓度高表明胚胎质量良好。
结论
FF中高LF浓度与高受精率和良好胚胎质量均相关。
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