Green S
Dept of Psychology, Birkbeck College, University of London, UK.
Trends Neurosci. 1991 Mar;14(3):101-4. doi: 10.1016/0166-2236(91)90070-b.
Anxiety is a complex state that includes a broad range of classified symptoms. Anxiolytic treatment has been dominated by the use of benzodiazepine drugs (BZs), which is often prolonged. However, the multiplicity of anxiety states and the lack of BZ specificity preclude the potent targeting of the drugs to different states, and point to the problem of drug dependence. Furthermore, animal models of anxiety give different results when challenged with apparently similar drugs. The search for alternative drugs with a higher specificity has led to 5-HT receptor subtypes. In this review, Simon Green describes how recent research might have dual benefits: in improving drug therapy of anxiety in humans, and in analysing and categorizing more clearly the concept of anxiety itself.
焦虑是一种复杂的状态，包括一系列广泛的分类症状。抗焦虑治疗一直以使用苯二氮䓬类药物（BZs）为主，这种使用往往持续时间较长。然而，焦虑状态的多样性以及BZ缺乏特异性，使得这些药物无法有效地针对不同状态，还存在药物依赖问题。此外，当用看似相似的药物进行挑战时，焦虑的动物模型会给出不同的结果。对具有更高特异性的替代药物的探索导致了对5-羟色胺受体亚型的研究。在这篇综述中，西蒙·格林描述了最近的研究如何可能带来双重益处：改善人类焦虑症的药物治疗，以及更清晰地分析和分类焦虑本身的概念。
