Turkish Aaron, Sturley Stephen L
Department of Pediatrics, Columbia University Medical Center, 650 W. 168th St., New York, NY 10032, USA.
Am J Physiol Gastrointest Liver Physiol. 2007 Apr;292(4):G953-7. doi: 10.1152/ajpgi.00509.2006. Epub 2006 Nov 9.
Esterification of sterols, fatty acids and other alcohols into biologically inert forms conserves lipid resources for many cellular functions. Paradoxically, the accumulation of neutral lipids such as cholesteryl ester or triglyceride, is linked to several major disease pathologies. In a remarkable example of genetic expansion, there are at least eleven acyltransferase reactions that lead to neutral lipid production. In this review, we speculate that the complexity and apparent redundancy of neutral lipid synthesis may actually hasten rather than impede the development of novel, isoform-specific, therapeutic interventions for acne, type 2 diabetes, obesity, hyperlipidemia, fatty liver disease, and atherosclerosis.
将固醇、脂肪酸和其他醇类酯化形成生物惰性形式，可为许多细胞功能保存脂质资源。矛盾的是，中性脂质如胆固醇酯或甘油三酯的积累与几种主要疾病病理相关。在一个显著的基因扩展例子中，至少有十一种酰基转移酶反应会导致中性脂质的产生。在本综述中，我们推测中性脂质合成的复杂性和明显冗余性实际上可能会加速而非阻碍针对痤疮、2型糖尿病、肥胖症、高脂血症、脂肪肝疾病和动脉粥样硬化的新型、亚型特异性治疗干预措施的开发。
