Cancer Biology Lab, MMG, University of the Punjab, Lahore, 54590, Pakistan.
Bundesanstalt für Materialforschung und -prüfung (BAM), Department of Analytical Chemistry, Richard-Willstätter-Straße 11, 12489, Berlin, Germany.
Br J Cancer. 2019 Jun;120(12):1090-1098. doi: 10.1038/s41416-019-0451-4. Epub 2019 May 16.
Cancer cells are often exposed to a metabolically challenging environment with scarce availability of oxygen and nutrients. This metabolic stress leads to changes in the balance between the endogenous synthesis and exogenous uptake of fatty acids, which are needed by cells for membrane biogenesis, energy production and protein modification. Alterations in lipid metabolism and, consequently, lipid composition have important therapeutic implications, as they affect the survival, membrane dynamics and therapy response of cancer cells. In this article, we provide an overview of recent insights into the regulation of lipid metabolism in cancer cells under metabolic stress and discuss how this metabolic adaptation helps cancer cells thrive in a harsh tumour microenvironment.
癌细胞通常处于代谢挑战的环境中，氧气和营养物质的供应匮乏。这种代谢应激导致细胞内源性合成和外源性摄取脂肪酸的平衡发生变化，而脂肪酸是细胞进行膜生物发生、能量产生和蛋白质修饰所必需的。脂质代谢的改变，以及随之而来的脂质组成的改变，具有重要的治疗意义，因为它们影响癌细胞的存活、膜动力学和治疗反应。在本文中，我们概述了代谢应激下癌细胞中脂质代谢调控的最新研究进展，并讨论了这种代谢适应如何帮助癌细胞在恶劣的肿瘤微环境中茁壮成长。
