Savel J, Clostre F
Membre de l'Académie nationale de pharmacie, BP 68, F 75261 Paris Cedex 06.
Ann Pharm Fr. 2006 Sep;64(5):291-307. doi: 10.1016/s0003-4509(06)75322-6.
The Nematode Caenorhabditis elegans (C. elegans) is an established model increasingly used for studying human disease pathogenesis. C. elegans models are based on the mutagenesis of human disease genes conserved in this Nematode or on the transgenesis with disease genes not conserved in C. elegans. Genetic examinations will give new insights on the cellular and molecular mechanisms that are altered in some neurodegenerative diseases like Duchenne's muscular dystrophy, Huntington's disease and Alzheimer's disease. C. elegans may be used for primary screening of new compounds that may be used as drugs in these diseases.
线虫秀丽隐杆线虫（C. elegans）是一种成熟的模型，越来越多地用于研究人类疾病的发病机制。秀丽隐杆线虫模型基于该线虫中保守的人类疾病基因的诱变，或基于用秀丽隐杆线虫中不保守的疾病基因进行转基因。基因检测将为某些神经退行性疾病（如杜氏肌营养不良症、亨廷顿舞蹈症和阿尔茨海默病）中发生改变的细胞和分子机制提供新的见解。秀丽隐杆线虫可用于对可能用作这些疾病药物的新化合物进行初步筛选。
