Okano Y, Tochikubo O, Umemura S
The Department of Medical Science and Cardiorenal Medicine, Yokohama City University Graduate School of Medicine, Yokohama City, Japan.
J Hum Hypertens. 2007 Feb;21(2):135-40. doi: 10.1038/sj.jhh.1002117. Epub 2006 Nov 9.
There are many reports indicating that night time blood pressure (BP) is closely associated with target organ damage. However, BP in the waking period is influenced by physical activity and also by the psychological status. Recently, base BP (BP0: minimum and stable BP during sleep) has been reported to correlate with organ damage in hypertensives. However, little is known about the implications of BP0. We examined how BP0 is associated with BP, heart rate variability and health-related quality of life (HRQOL) in healthy subjects. One hundred and thirty-five participants, composed of 88 male and 47 female (age: 21-33 years) underwent a 24-h ambulatory BP monitoring (ABPM). Sympathetic nervous activity (ratio of low-frequency to high-frequency component: LF/HF) and parasympathetic nervous activity (high-frequency component: HF) were calculated by electrocardiogram monitoring. BP0 was calculated as previously reported. HRQOL was assessed by Medical Outcome Study Short-Forum 36-Item Health Survey. Base systolic BP (SBP0) positively correlated with 24-h systolic BP (SBP) (r=0.662, P<0.0001) and night time SBP (r=0.810, P<0.0001). SBP0 positively correlated with 24-h LF/HF (r=0.214, P<0.02) and night time LF/HF (r=0.326, P<0.001). Moreover, SBP0 negatively correlated with the scores of body pain (r=-0.223, P<0.02). Multiple linear regression analysis showed that SBP0 correlated with gender (P<0.01), night time LF/HF (P<0.04) and the scores of body pain (P<0.04). In conclusion, SBP0 correlated with BP, LF/HF and the scores of body pain (HRQOL). SBP0 may be a useful indicator for assessing 24-h BP, sympathetic nervous functions and HRQOL in healthy subjects.
有许多报告表明夜间血压（BP）与靶器官损害密切相关。然而，清醒期的血压受身体活动以及心理状态的影响。最近，基础血压（BP0：睡眠期间的最低且稳定的血压）已被报道与高血压患者的器官损害相关。然而，关于BP0的意义知之甚少。我们研究了健康受试者中BP0与血压、心率变异性及健康相关生活质量（HRQOL）之间的关系。135名参与者，包括88名男性和47名女性（年龄：21 - 33岁），接受了24小时动态血压监测（ABPM）。通过心电图监测计算交感神经活动（低频与高频成分之比：LF/HF）和副交感神经活动（高频成分：HF）。BP0按先前报道的方法计算。HRQOL通过医学结局研究简明健康调查36项量表进行评估。基础收缩压（SBP0）与24小时收缩压（SBP）呈正相关（r = 0.662，P < 0.0001）以及夜间SBP呈正相关（r = 0.810，P < 0.0001）。SBP0与24小时LF/HF呈正相关（r = 0.214，P < 0.02）以及夜间LF/HF呈正相关（r = 0.326，P < 0.001）。此外，SBP0与身体疼痛评分呈负相关（r = -0.223，P < 0.02）。多元线性回归分析表明SBP0与性别（P < 0.01）、夜间LF/HF（P < 0.04）和身体疼痛评分（P < 0.04）相关。总之，SBP0与血压、LF/HF及身体疼痛评分（HRQOL）相关。SBP0可能是评估健康受试者24小时血压、交感神经功能及HRQOL的有用指标。
