Okano Yasuko, Toya Yoshiyuki, Azuma Kouichi, Yabana Machiko, Tamura Kouichi, Umemura Satoshi
Medical Science and Cardiorenal Medicine, Yokohama City University School of Medicine, Kanagawa, Japan.
Nihon Jinzo Gakkai Shi. 2010;52(7):939-44.
We reported on the relationship between base blood pressure (BP), autonomic function and health-related quality of life (HRQOL) in healthy adults. The aim of the present study was to examine the relationship between the antihypertensive effects, autonomic function, and HRQOL following the treatment of hypertensive subjects with losartan/hydrochlorothiazide in hypertensives. In the 10 hypertensive patients treated with angiotensin receptor blockers for more than 1 month, combination therapy with losartan/hydrochlorothiazide was conducted for 3 months after the cessation of treatment with angiotensin receptor blockers. Either immediately before the onset of combination therapy or 3 months after the treatment, 24-h ambulatory BP and pulse wave velocity (PWV) were measured. Sympathetic nervous activity (ratio of low frequency to high frequency component: LF/HF) and parasympathetic nervous activity (high frequency component: HF) were calculated by heart rate variability. Quality of life (HRQOL) was assessed by the Medical Outcome Study Short-Forum 36-Item Health Survey (SF-36). All of the participants completed the study. Losartan/hydrochlorothiazide combination therapy reduced base BP(from 114 +/- 5 to 100 +/- 3 mmHg; p < 0.03)and 24-h LF/HF (from 1.48 +/- 0.18 to 0.94 +/- 0.20; p < 0.02). However, heart rates and PWV were not influenced by losartan/hydrochlorothiazide treatment. The HRQOL scores improved during the study (p < 0.05). These findings indicated that losartan/hydrochlorothiazide was associated with an improvement in base BP relative to daytime BP, autonomic function and HRQOL.
我们报告了健康成年人基础血压（BP）、自主神经功能与健康相关生活质量（HRQOL）之间的关系。本研究的目的是探讨高血压患者接受氯沙坦/氢氯噻嗪治疗后的降压效果、自主神经功能与HRQOL之间的关系。在10例接受血管紧张素受体阻滞剂治疗超过1个月的高血压患者中，在停止血管紧张素受体阻滞剂治疗后，进行氯沙坦/氢氯噻嗪联合治疗3个月。在联合治疗开始前或治疗3个月后，测量24小时动态血压和脉搏波速度（PWV）。通过心率变异性计算交感神经活动（低频与高频成分之比：LF/HF）和副交感神经活动（高频成分：HF）。生活质量（HRQOL）通过医学结局研究简版36项健康调查（SF-36）进行评估。所有参与者均完成了研究。氯沙坦/氢氯噻嗪联合治疗降低了基础血压（从114±5降至100±3 mmHg；p<0.03）和24小时LF/HF（从1.48±0.18降至0.94±0.20；p<0.02）。然而，心率和PWV不受氯沙坦/氢氯噻嗪治疗的影响。在研究期间，HRQOL评分有所改善（p<0.05）。这些发现表明，氯沙坦/氢氯噻嗪与基础血压相对于日间血压、自主神经功能和HRQOL的改善有关。
