Colgan T J, Dardick I, O'Connell G
Department of Pathology, University of Toronto, Ontario, Canada.
Int J Gynecol Pathol. 1991;10(2):203-8. doi: 10.1097/00004347-199104000-00009.
A case of vulvar paraganglioma is reported. Following presentation with vulvar pain, a 1-cm nodule was excised from the labium minus of a 58-year-old woman. Histologically, the tumor was composed of nests of round eosinophilic cells with moderately pleomorphic nuclei, beneath an intact squamous epithelium. Ultrastructural studies indicated two cell types within the neoplasm: chief cells with numerous small neurosecretory granules and peripheral slender sustentacular cells. A reticulin stain confirmed the "zellballen" nature of the neoplasm, and the neoplastic cells showed moderate argyrophilia on a Grimelius stain. The immunoperoxidase stains for chromogranin and neuron-specific enolase were strongly positive in the neoplastic chief cells. Immunostaining using anti-S-100 antibody confirmed the finding of sustentacular cells by identifying many slender cellular processes among the chief cells. These light and electron microscopic findings are diagnostic of paraganglioma, an entity not previously reported in the vulva to our knowledge.
本文报告一例外阴副神经节瘤。一名58岁女性因外阴疼痛就诊，其小阴唇切除了一个1厘米的结节。组织学上，肿瘤由圆形嗜酸性细胞巢组成，细胞核中度多形性，位于完整的鳞状上皮下方。超微结构研究表明肿瘤内有两种细胞类型：含有大量小神经分泌颗粒的主细胞和周围细长的支持细胞。网状纤维染色证实了肿瘤的“细胞巢”性质，肿瘤细胞在吉姆萨染色中显示中度嗜银性。嗜铬粒蛋白和神经元特异性烯醇化酶的免疫过氧化物酶染色在肿瘤主细胞中呈强阳性。使用抗S-100抗体的免疫染色通过在主细胞中识别许多细长的细胞突起，证实了支持细胞的存在。这些光镜和电镜检查结果可诊断为副神经节瘤，据我们所知，这是一种此前未在外阴报道过的疾病。
