Sakamoto F, Ito M, Matumura G, Sato Y, Kimura S
Department of Dermatology, Niigata University School of Medicine, Japan.
J Cutan Pathol. 1991 Apr;18(2):128-33. doi: 10.1111/j.1600-0560.1991.tb00140.x.
A tumor of 60 years' duration overlying the sternum of an 87-year-old woman is described. Histologically, the tumor was composed of lobules and cords of epithelial cells with finely granular, eosinophilic cytoplasm. The epithelial nests were floating in large pools of mucinous stroma, separated by thin fibrovascular septa. Cytoplasmic argyrophilia was seen by Grimelius silver stain. Positive reactions of the tumor cells were also found for chromogranin and neuron-specific enolase. Ultrastructural study revealed that the cytoplasm of the tumor cells contained two types of granules: neurosecretory and mucinous. From these findings, the present tumor is considered to be a carcinoid tumor with amphicrine cells, and the term "mucinous carcinoid" of the skin seems to be appropriate for the diagnosis of the present case.
本文描述了一位87岁女性胸骨上方持续60年的肿瘤。组织学上，肿瘤由上皮细胞小叶和索条组成，细胞质呈细颗粒状、嗜酸性。上皮巢漂浮在大量黏液性间质池中，由薄的纤维血管间隔分隔。Grimelius银染色可见细胞质嗜银性。肿瘤细胞对嗜铬粒蛋白和神经元特异性烯醇化酶也呈阳性反应。超微结构研究显示，肿瘤细胞的细胞质含有两种类型的颗粒：神经分泌颗粒和黏液颗粒。基于这些发现，目前的肿瘤被认为是一种具有双分泌细胞的类癌肿瘤，“皮肤黏液性类癌”这一术语似乎适用于本病例的诊断。
