Clasen C, Wilhelms T, Kulicke W-M
Institute of Technical and Macromolecular Chemistry, University of Hamburg, 20146 Hamburg, Germany.
Biomacromolecules. 2006 Nov;7(11):3210-22. doi: 10.1021/bm060486x.
In this paper, hydrophilic polymer membranes based on macromolecular chitosan networks have been synthesized and characterized. The structure of the membrane has been altered in several ways during the formation to adjust the properties, particularly with regard to the elasticity, tensile strength, permeability, and surface structure. An alteration of the network structure was achieved by addition of flexibilizer, cross-linking with dialdehydes, symplex formation of the chitosan with the polyanion sulfoethyl cellulose, and the introduction of artificial pores on the micro- and nanometer scale into the chitosan matrix with silica particles or poly(ethylene glycol). The resulting network structures and morphologies of these unique membranes that combine the novel alteration techniques have been characterized in detail and correlated with molecular parameters of the chitosan as degree of deacetylation, molar mass, and charge density. Finally, we report on the impact of the new network structures on physical properties of the membranes, the water vapor and gas permeability and the tensile strength, to evaluate possible application of the membranes as a wet wound dressing material with microbial barrier function that actively assists the healing process of problematic wounds. Parts of the novel combined membrane alteration and formation techniques are now covered by the patent DE 102004047115.
本文合成并表征了基于大分子壳聚糖网络的亲水性聚合物膜。在膜的形成过程中，通过多种方式改变其结构以调节性能，特别是在弹性、拉伸强度、渗透性和表面结构方面。通过添加增塑剂、与二醛交联、壳聚糖与聚阴离子磺基乙基纤维素形成复合物以及用二氧化硅颗粒或聚乙二醇在微米和纳米尺度上在壳聚糖基质中引入人工孔来实现网络结构的改变。详细表征了结合这些新型改变技术的独特膜的所得网络结构和形态，并将其与壳聚糖的分子参数（如脱乙酰度、摩尔质量和电荷密度）相关联。最后，我们报告了新网络结构对膜的物理性能、水蒸气和气体渗透性以及拉伸强度的影响，以评估这些膜作为具有微生物屏障功能的湿性伤口敷料材料的可能应用，该材料可积极辅助有问题伤口的愈合过程。部分新型组合膜改变和形成技术现已被专利DE 102004047115涵盖。
