Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues.
作者信息
Fioravanti Stefania, Pellacani Lucio, Tardella Paolo A, Morreale Alberto, Del Signore Giuseppe
机构信息
Dipartimento di Chimica, Università degli Studi La Sapienza, P.le Aldo Moro 2, I-00185 Roma, Italy.
出版信息
J Comb Chem. 2006 Nov-Dec;8(6):808-11. doi: 10.1021/cc060029k.
PMID:17096568
Abstract
A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.
摘要
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