Fioravanti Stefania, Massari Davide, Morreale Alberto, Pellacani Lucio, Tardella Paolo A
Dipartimento di Chimica, Università degli Studi 'La Sapienza', P.le Aldo Moro 2, I-00185 Roma, Italy.
Tetrahedron. 2008 Mar 31;64(14):3204-3211. doi: 10.1016/j.tet.2008.01.098. Epub 2008 Jan 31.
Starting from a library of 2-l-α-amino acyl ()-acrylonitriles, different short 2-cyano and 2-amido aziridinyl peptides, potential protease inhibitors, were obtained under parallel solution-phase conditions. The transformations include careful selection of conditions for aziridine deprotection and cyano group partial hydrolysis.
从一个2-L-α-氨基酰基（）-丙烯腈文库出发，在平行溶液相条件下获得了不同的短2-氰基和2-酰胺基氮杂环丙烷基肽，即潜在的蛋白酶抑制剂。这些转化包括仔细选择氮杂环丙烷脱保护和氰基部分水解的条件。
