Dömling Alexander, Beck Barbara, Fuchs Thilo, Yazbak Ahmad
ABC-Pharma, Franckensteinstrasse 9a, 81243 München, Germany.
J Comb Chem. 2006 Nov-Dec;8(6):872-80. doi: 10.1021/cc060068w.
Arrays of amino-acid-derived isocyanoamides are conveniently produced on a multigram scale in one step by the solventless aminolysis of the corresponding methyl esters with primary or secondary aliphatic amines. Most of the corresponding isocyanides precipitate during the reaction and can be filtered to yield highly pure, colorless, and odorless solids. They are potentially useful in the combinatorial chemistry of multicomponent reactions.
通过用伯或仲脂肪胺对相应的甲酯进行无溶剂氨解反应，可方便地一步法以多克规模制备氨基酸衍生的异氰基酰胺阵列。大多数相应的异腈在反应过程中沉淀出来，经过过滤可得到高纯度、无色且无味的固体。它们在多组分反应的组合化学中具有潜在用途。
