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Concise Synthesis of Tetrazole-keto-piperazines by Two Consecutive Ugi Reactions.

作者信息

Zarganes-Tzitzikas Tryfon, Patil Pravin, Khoury Kareem, Herdtweck Eberhardt, Dömling Alexander

机构信息

Department of Drug Design, University of Groningen, Antonius Deusinglaan 1, Postbus 196, 9700 AD Groningen, Netherlands, Homepage: www.drugdesign.nl.

Carmolex Inc., 2000 Technology Drive Suite 100, Pittsburgh, Pennsylvania 15219 United States, Homepage: www.carmolex.com.

出版信息

European J Org Chem. 2015 Jan;2015(1):51-55. doi: 10.1002/ejoc.201403401. Epub 2014 Nov 17.

DOI:10.1002/ejoc.201403401
PMID:26949370
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4774864/
Abstract
摘要

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6
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9
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