早期复发缓解型多发性硬化症中与教育水平相关的认知代偿证据。
Evidence of cognitive compensation associated with educational level in early relapsing-remitting multiple sclerosis.
作者信息
Bonnet Melissa C, Deloire Mathilde S A, Salort Emmanuelle, Dousset Vincent, Petry Klaus G, Brochet Bruno
机构信息
EA 2966, Neurobiology of Myelin Disorders Laboratory, University Victor Segalen, Bordeaux, France.
出版信息
J Neurol Sci. 2006 Dec 21;251(1-2):23-8. doi: 10.1016/j.jns.2006.08.002. Epub 2006 Nov 13.
BACKGROUND
Cognitive compensatory mechanisms may limit the cognitive dysfunction due to cerebral tissue destruction in multiple sclerosis (MS).
OBJECTIVE
To explore the effect of educational status on cognitive performances in early relapsing-remitting (RR) MS.
METHODS
43 RRMS patients were individually matched for age, sex and educational level with 43 healthy controls. Each patient underwent neuropsychological tests, clinical assessment and magnetic resonance imaging (MRI). Cognitive scores of MS patients were compared to those of their paired controls according to educational level.
RESULTS
Less educated patients had low performances on all but two neuropsychological tests, while more educated patients had low scores only for three tests. Cognitive performances of more educated patients but not those of less educated ones were strongly correlated with MRI parameters and decreased with the severity of cerebral tissue destruction.
CONCLUSION
These different cognitive patterns suggest the existence of a cognitive compensation in more educated patients which is limited by the accumulation of tissue damage.
背景
认知补偿机制可能会限制多发性硬化症（MS）中脑组织破坏所致的认知功能障碍。
目的
探讨教育程度对早期复发缓解型（RR）MS患者认知表现的影响。
方法
43例RRMS患者在年龄、性别和教育水平方面与43名健康对照个体进行匹配。每位患者均接受神经心理学测试、临床评估和磁共振成像（MRI）检查。根据教育水平，将MS患者的认知得分与其配对对照的得分进行比较。
结果
受教育程度较低的患者在除两项之外的所有神经心理学测试中表现较差，而受教育程度较高的患者仅在三项测试中得分较低。受教育程度较高患者的认知表现与MRI参数密切相关，而受教育程度较低患者则不然，且随着脑组织破坏程度的加重而下降。
结论
这些不同的认知模式表明，受教育程度较高的患者存在认知补偿现象，但这种补偿会受到组织损伤积累的限制。
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