Shim Seong S, Hammonds Micheal D, Ganocy Stephen J, Calabrese Joseph R
Department of Psychiatry, NIMH Center for Bipolar Disorder, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Prog Neuropsychopharmacol Biol Psychiatry. 2007 Mar 30;31(2):343-7. doi: 10.1016/j.pnpbp.2006.09.008. Epub 2006 Nov 9.
Although it has long been suggested that lithium has robust neuroplastic actions, and these actions lead to an enhancement on synaptic plasticity, the effects of lithium treatment on synaptic plasticity have been rarely studied. This study examined the effects of sub-chronic lithium treatment on synaptic plasticity in the dentate gyrus (DG) of hippocampal slices in the rats. Young adult rats were intraperitoneally administered a daily dose of 1 mgEq LiCl or saline-vehicle for 14 days. Twelve hours after the last injections, the input/output (I/0) responses of field excitatory postsynaptic potentials (fEPSP) and the long-term potentiation (LTP) of fEPSP and population spikes (PS) were determined in the DG of hippocampal slices prepared from the animals treated with lithium or vehicle. Treatment of lithium for 14 days significantly increased the I/O responses of fEPSP and the LTP of fEPSP and PS. These results indicate that sub-chronic treatment of lithium increases the excitatory postsynaptic responses, synaptic strength and the cell firing of the granule cells in the DG of the hippocampus.
尽管长期以来一直有人认为锂具有强大的神经可塑性作用，且这些作用会增强突触可塑性，但锂治疗对突触可塑性的影响却鲜有研究。本研究检测了亚慢性锂治疗对大鼠海马切片齿状回（DG）突触可塑性的影响。将年轻成年大鼠每天腹腔注射1 mgEq LiCl或生理盐水载体，持续14天。最后一次注射12小时后，在由锂或载体处理的动物制备的海马切片的DG中测定场兴奋性突触后电位（fEPSP）的输入/输出（I/0）反应以及fEPSP和群体峰电位（PS）的长时程增强（LTP）。锂治疗14天显著增加了fEPSP的I/O反应以及fEPSP和PS的LTP。这些结果表明，锂的亚慢性治疗增加了海马DG中颗粒细胞的兴奋性突触后反应、突触强度和细胞放电。
